The Laboratory of Lawrence Lit King Leung, MD
Various Images
Model of Human Thrombin
Space filling model of human thrombin in the "standard" orientation, looking directly into the active site cleft.
Localization of functional domains on the surface of thrombin. Residues involved in the recognition of fibrinogen TM-dependent protein C activation. Blue residues are involved only in fibrinogen recognition, yellow residues only in TM-dependent PC activation, and green residues are involved in both functions.
Exosite I residues lying to the right of the active site are in green.
Residue E229, the site mutated to generate the Protein C activators E229A and E229K.
SDS-PAGE of purifcation process for thrombin mutants.